Recruiting Crohn’s disease
TARGET-CD
Targeted treatments for Crohn's disease
This trial tests targeted treatments for moderate to severe Crohn's disease. The arm currently open in Edinburgh studies ABBV-8736, followed by maintenance treatment with risankizumab from week 24.
Interventional · phase 2a
Study details for TARGET-CD
Who the study is for
- Adults with moderate to severe Crohn's disease
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Regular clinic visits, with colonoscopies at screening and weeks 12 and 24. Visits continue through week 36, then every eight weeks during maintenance treatment.
Study reference: NCT06548542
Official study information ↗Recruiting Crohn’s disease
VICTRIVA
Combining vedolizumab and upadacitinib
This trial compares vedolizumab plus upadacitinib with vedolizumab plus placebo during the first 12 weeks of treatment. It then follows response during maintenance treatment with vedolizumab.
Interventional · phase 3b
Study details for VICTRIVA
Who the study is for
- Adults aged 18–65 with moderate to severe Crohn's disease
- Previous treatment has not worked well enough, has stopped working or could not be tolerated
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Treatment visits through week 52, with colonoscopies at screening and weeks 12 and 52, followed by a safety follow-up. A substudy may involve visits every four weeks.
Study reference: NCT06227910
Official study information ↗Recruiting Crohn’s disease
VECTORS
Using intestinal ultrasound to guide treatment
This study investigates whether adding ultrasound assessments of healing through the bowel wall to treatment targets can improve care for people receiving vedolizumab.
Interventional
Study details for VECTORS
Who the study is for
- People with moderately to severely active Crohn's disease
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Visits through week 96, including intestinal ultrasound assessments and colonoscopies at screening and week 48.
Study reference: NCT06257706
Official study information ↗Recruiting All IBD
Open-IBD
Understanding IBD from the start
Open-IBD follows people being investigated for possible IBD. It connects blood, stool and tissue samples with health information to understand why the disease develops and how it changes over time.
Observational
Study details for Open-IBD
Who the study is for
- People being investigated for a suspected diagnosis of IBD
- The study also follows people whose investigations do not lead to an IBD diagnosis
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Sample collection, questionnaires and health-record review over two years, with possible follow-up at years three and four. Biopsies are sought at baseline and month 12. Follow-up for people without IBD uses health records without study visits.
Study reference: IRAS 345768
Official study information ↗Recruiting Ulcerative colitis
ACESO
Additional treatment for acute severe ulcerative colitis
ACESO investigates adding upadacitinib to corticosteroids early in the treatment of acute severe ulcerative colitis. Participants receive either upadacitinib or placebo alongside corticosteroids.
Interventional · phase 3
Study details for ACESO
Who the study is for
- People admitted to hospital with acute severe ulcerative colitis
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Assessments during the early hospital treatment period, followed by checks at days 10 and 15, weeks four and eight, and 12 months.
Study reference: ISRCTN17100156
Official study information ↗Recruiting Crohn’s disease
GONDOMAR
Understanding perianal fistulas in Crohn's disease
This study uses clinical information to understand the course and treatment of perianal Crohn's fistulas, which are abnormal connections between the bowel and the skin around the anus.
Observational
Study details for GONDOMAR
Who the study is for
- People with perianal fistulas associated with Crohn's disease
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
For the prospective group, health records are reviewed every six months for three years after consent. A separate retrospective group involves review of earlier records.
Study reference: IRAS 300534
Recruiting All IBD
IBD BioResource
Connecting genetics with better IBD care
The UK IBD BioResource supports research into Crohn's disease and ulcerative colitis, helping researchers connect genetic findings with how the diseases work and how care might improve.
Observational
Study details for IBD BioResource
Who the study is for
- Adults, young people and children with Crohn's disease or ulcerative colitis
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
An initial study appointment. The research team can explain what joining involves and any future opportunities to contribute.
Study reference: IRAS 173561
Recruiting Crohn’s disease
OCEaN
Nutrition before Crohn's surgery
OCEaN compares a prescribed liquid nutrition programme before surgery with usual diet, to find out whether it improves recovery after an operation for Crohn's disease.
Interventional
Study details for OCEaN
Who the study is for
- People with Crohn's disease who are preparing for surgery
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Assessments before surgery, questionnaires shortly afterwards, and follow-up at six, 24 and 52 weeks after surgery.
Study reference: ISRCTN73953171
Official study information ↗Recruiting Bile acid diarrhoea
Bile acid diarrhoea study
Investigating colesevelam for bile acid diarrhoea
This double-blind study investigates colesevelam as a treatment for bile acid diarrhoea. The research team can explain the treatment groups and the criteria for taking part.
Interventional · phase 2
Study details for Bile acid diarrhoea study
Who the study is for
- People with bile acid diarrhoea
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
Screening and baseline visits, then clinic visits at days 28, 56 and 84, with telephone checks between visits.
Study reference: REC 24/SS/0075
Recruiting All IBD
GUSTO
Following guselkumab treatment in routine care
This observational study collects information about guselkumab treatment in people with Crohn's disease or ulcerative colitis.
Observational
Study details for GUSTO
Who the study is for
- People with Crohn's disease or ulcerative colitis receiving guselkumab
This is a short overview. The research team will check the full study criteria with you.
Visits and follow-up
A baseline study assessment. The team can explain any further information collected during routine care.
Study reference: REC 25/PR/0923